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PDS Biotechnology partners with NCI

Feb 9, 2016
-
News, PDS Biotechnology, RNS Announcements
RNS Number : 5158O
NetScientific PLC
09 February 2016

 

NetScientific plc

PDS Biotechnology partners with National Cancer Institute in Phase II clinical trials for novel cancer immunotherapies

London, UK – 9 February 2016 – NetScientific plc (“NetScientific” or the “Group”, AIM: NSCI), the transatlantic biomedical and healthcare technology group, is pleased to note that one of its portfolio companies, PDS Biotechnology, has signed a Cooperative Research and Development Agreement with the National Cancer Institute, a division of the US National Institutes of Health. The goal is to co-develop novel cancer immunotherapies through Phase II clinical trials that will start in 2016 and 2017.

Commenting on the news, NetScientific’s Chief Executive Officer, Francois R. Martelet said: “Securing a cooperative research and development agreement with the leading cancer research institute in the US is a landmark moment for PDS Biotechnology and a huge endorsement of its technology. Versamune® has been shown to be applicable to potentially a wide range of cancers and this deal will be key to further advancing immunotherapy clinical research.“

The full text of the announcement from PDS Biotechnology can be found below.

Contact Details

NetScientific

François R. Martelet, M.D., CEO

Mark Nanovich, Interim CFO

Tel: +44 (0)20 3514 1800

 

Investec (NOMAD and broker)

Gary Clarence / Daniel Adams

Tel: +44 (0)20 7597 4000

 

Instinctif Partners

Melanie Toyne-Sewell / Jayne Crook / Rosanna Forrest

Tel: +44 (0)20 7457 2020 Email: netscientific@instinctif.com

 

 

PDS Biotechnology Signs Agreement with National Cancer Institute to form Phase II clinical collaboration for novel cancer immunotherapies based on PDS’ Versamune® platform technology

 

 

-Clinical Co-Development of Immunotherapies to treat Prostate, Breast, and HPV-related Cancers-

 

North Brunswick, New Jersey February 9, 2016 (PR NEWSWIRE) – PDS Biotechnology (PDS), a clinical-stage biopharmaceutical company focused on developing a pipeline of simpler, safer and more effective cancer immunotherapies based on its novel Versamune® platform, today announced that the Company has signed a Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI), an Institute of the U.S. National Institutes of Health.  Under the CRADA, PDS and NCI aim to co-develop several immunotherapies through Phase II clinical trials to be initiated in 2016 and 2017, utilizing combinations of Versamune® with NCI- and PDS-sourced tumor-related proteins or their fragments recognized by the immune system (antigens) in prostate, breast, and HPV-related cancers.

 

The PDS-NCI CRADA collaboration is led by Jay A. Berzofsky, M.D., Ph.D., Chief of the NCI Center for Cancer Research (CCR) Vaccine Branch, Lauren V. Wood, M.D., Head of the NCI CCR Vaccine Branch Clinical Trials Team, and Masaki Terabe, Ph.D., Deputy Section Chief of the NCI CCR Vaccine Branch. The CRADA encompasses Phase II clinical development, starting in late 2016, of antigen-specific immunotherapies for multiple cancers, as well as additional preclinical studies combining the Versamune® platform with specific technologies to generate potent antigen-specific and natural killer T-cell anti-tumor immune responses.

 

“The Versamune® platform, based on preclinical and Phase I human clinical studies, has demonstrated the potential to overcome the most critical obstacles facing cancer vaccine technologies.  Versamune® enables the design of simple subcutaneous immunotherapies that efficiently deliver tumor antigens to the patient’s own immune system, while simultaneously stimulating the generation of potent tumor-killing T-cells that can overcome the tumor’s immuno-suppressive environment.  We are very pleased to have the opportunity to collaborate with Drs. Berzofsky, Wood, and Terabe, to extend the clinical progress that has been achieved to date with our Versamune® platform and the immunotherapy field in general” said Frank Bedu-Addo, Ph.D., PDS’s President and Chief Executive Officer.

 

About Versamune®: 

Versamune® is a clinical stage and synthetic lipid-based immunotherapy platform.  Due to its unusual combination of high safety and potent killer (CD8+) T-cell induction in humans, Versamune® has demonstrated the potential to achieve a key goal of cancer immunotherapy: to effectively prevent and treat cancer in its most treatable early stages.  Versamune® is unique in its demonstrated potential to activate all three critical immunotherapy mechanisms, improving the potential for effective anti-tumor effect upon simple subcutaneous injection. The Versamune® platform is now being applied to the development of multiple Phase II clinical-stage cancer products, including both early and late-stage cancer indications.

 

About PDS Biotechnology

PDS Biotechnology is a private biopharmaceutical company with a growing pipeline of simpler, safer, and more effective clinical-stage immunotherapies to treat various early-stage and late-stage cancers.  PDS is completing its first oncology human clinical trial and expects to report these Phase I study results in the very near future.  PDS is also applying the versatile Versamune® platform to the prevention of selected pandemic diseases.

 

About NetScientific

NetScientific is a biomedical and healthcare technology group that funds and develops technologies that offer transformative benefits to people’s lives and society through improved diagnosis, prognosis and treatment.

For more information, please visit the website at www.netscientific.net.  

 

– Ends –

This information is provided by RNS
The company news service from the London Stock Exchange

END

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